Belle is 75 pounds, she is big and her urine is lethal to everything she urinates on. If she pees on it today, dead tomorrow. We have tried pills from the pet stores, no difference. We have also tried watering directly after she goes, helps a little. We thought when we had a smaller yard it was because she did not have enough room to spread out her lethal urine. We now have an acre, nope, Belle is still the best grass killer around. We did a bit of research on WHY her urine kills all the grass. Her urine is acidic. Baking soda is a base and when we have mixed about 1/2 of a cup of baking soda in a gallon of water, it has been effective. But only after directly applying it to the urine on the grass seconds after she pees. When the grass is dead, it is dead, no bringing it back to life, you will have to start over, replant grass. We are still using the urine pills from the local pet store in conjunction with our water mix. We have the jug right outside of the door that leads to the back yard. If my husband uses the last in the jug, he fills it up, if I use the last in the jug, I fill it up. This way there is always grass saving water available and never an excuse to not use it. We love our green grass. Hope this helps you to prevent dead spots in your yard too!
Belle is such a big dog and we use baking soda in with our laundry as well. This is the kind we get-the big bag.